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“Then there was the educated Texan from Texas who looked like someone in Technicolor and felt, patriotically, that people of means – decent folk – should be given more votes than drifters, whores, criminals, degenerates, atheists and indecent folk – people without means.”Joseph Heller

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Biochemistry: Dereplication, Sequencing, Identification of Peptidic Products

Dereplication, sequencing and identification of peptidic natural products: from genome mining to peptidogenomics to spectral networks


Covering: 2000 to 2015. While recent breakthroughs in the discovery of peptide antibiotics and other Peptidic Natural Products (PNPs) raise a challenge for developing new algorithms for their analyses, the computational technologies for high-throughput PNP discovery are still lacking. We discuss the computational bottlenecks in analyzing PNPs and review recent advances in genome mining, peptidogenomics, and spectral networks that are now enabling the discovery of new PNPs via mass spectrometry. We further describe the connections between these advances and the new generation of software tools for PNP dereplication, de novo sequencing, and identification.

Biochemistry: Polyketides

Polyketides are a diverse class of compounds that are often created by a series of modular enzymes which condense and then modify chains of acetate or propionate units primarily through reduction, dehydration, cyclization, and aromatization reactions.


Also BioArchiv and ChemArchiv.

Biochemistry: Cubane (C8H8 compound)

Biochemistry: Human Genome

Biochemistry: Ubiquitin Regulates Aging

Biochemistry: Dalton Mole Equivalency
The number 6.02214076×10^23 (the Avogadro number) was chosen so that the mass of one mole of a chemical compound in grams is numerically equal, for most practical purposes, to the average mass of one molecule of the compound in daltons. Thus, for example, one mole of water (H2O) contains 6.02214076×1023 molecules, whose total mass is about 18.015 grams and the mean mass of one molecule of water is about 18.015 daltons.

Biography: John Brown (abolitionist)

Biography: John Taylor Gatto

Biography: Lysander Spooner

Biohemistry: NIST Mass Spectral Library Data + Peptide Library

Mass Spectral Library + Other Tools and Peptide Library.

NIST Mass Spectrometry Data Center - in the Biomolecular Measurement Division (BMD) - develops evaluated mass spectral libraries and provides related software tools. These products are intended to assist compound identification by providing reference mass spectra for GC/MS (by electron ionization) and LC-MS/MS (by tandem mass spectrometry) as well as gas phase retention indices for GC. The Center is located on the NIST main campus in Gaithersburg, MD.

Bios: Mikhail Lesin
Mikhail Lesin @ Wikipedia Article.

Biotech:  Super-VT - IV Vitamin Therapy Concierge Service 
See details of Super-VT IV Vitamin Therapy Concierge Service vitamin IV therapy London-based service on supervitiv.com website.

Biotech: ivbooks.uk London IV concierge
IV Treatments - Mitogive S-Acetyl Glutathione Therapy at ivboost.uk concierge service London.

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There are currently 4 definitions in this directory beginning with the letter B.

propagandist print media inclusion to discredit something heterodox

bidirectional digital media
B.D.D.M. (as it is called) is a coverall term for social media but also academic non-local learning - popular during the coronavirus pandemic

the blockchain is an append-only data structure composed of subunits called blocks - [blocks] are permanently ‘chained’ together - in practice, the blockchain is an immutable medium because it contains instructions in the form of computer code replicated across thousands of nodes much like DNA [is replicated] in cells
  • Emergent Bioanalogous Properties of Blockchain-based Distributed Systems

  • blockchain nodes
    nodes on the blockchain are important because rather than a central administrator maintaining a big computer server in one location (and controlling everything going in and out of it), the blockchain database is distributed as many identical encrypted copies across a large network of multiple computers - the nodes somewhat like cells which contain many identical copies of DNA
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    There are currently 3 thoughts in this directory beginning with the letter B.

    Big Pharma Vaccine Patent Sharing

    Pfizer/Moderna (i.e. NIH under US President - the patent holder) aren't sharing their vaccine recipe because they need to protect the mRNA platform, quite separately from the debate over proliferating vaccination against SARS-CoV-2 in the context of saving lives in the Coronavirus pandemic.

    It's possible the big pharmaceutical corporations don't object to letting poor countries make their own vaccines. The problem is with sharing the mRNA platform itself - specifically - because it is a multipurpose technology way beyond targeting spike proteins with potential for revenue streams that dwarf the billions made from SARS-CoV-2.

    The mRNA platform has myriad uses as a cancer delivery drug, which is perhaps the biggest prize in medical science - a bonanza of incalculable trillions that could roll on and on for decades. This is why the patent isn't going to be shared. It won't be shared until the technology can be shared in a way that doesn't open access beyond targeted Coronavirus usage. The vaccine corporations will doubtless be working on a nerfed version. If they find it, there will be a mainstream media fanfare of "patent sharing"; and a feeding frenzy over much unearned but irresistible political capital.

    Borrowed Energy - Awakenings Depression

    The movie Awakenings is set in a sanitarium full of patients in an awake catatonic state. In the film, a psychiatrist performs a strange experiment. He throws a tennis ball at one of the long-term catatonics and despite having been frozen for decades, since childhood, the patient catches the ball. No other movement. Still catatonic after. It's like the patient borrows the kinetic energy of the ball - overcoming the catatonic state, but only for that moment.

    This is how my engagement with the world works, nowadays, with social media and infowars and "neoliberal" consumerism.

    There's a headline, an article, a conversation. It has a kinetics of context and a background that might animate a fleeting interest, empathy, research - usually leading to an opinion - a conclusion, a placement within the bigger picture of society and what people do.

    Then the energy is spent. No more attention to be given, no natural engagement follows. Nothing lasts. The catatonic mindset returns. Nothing changes, except perhaps an imperceptible cold petrification that began years ago, at the extremities, and has been very slowly spreading inward towards the heart.


    Breaking The Erasure Paradigm

    Some guys defy odds to make a difference. Most are content being more Ballerina than reformed fat slob endurance runner David Goggins. Now and then fate gives an individual the chance to challenge their inner mettle and - very occasionally - it comes with a public stage.

    Cancel culture has been perverted into a wanton spectacle of coordinated hearsay, erasing anyone it touches. There's no recourse, no appeal, no end to cancellation. The smallest offence to prurient public opinion carries as severe a punishment as the most egregious.


    Someone's got to show the world how to resist; how to break the paradigm of perpetual erasure.

    Someone's got to figure a way through the coruscating glare of public bloodlust, to reach those who know and support the individual.

    That reconnection may have power to build new foundations, fortified against being sacrificed by the mob to feed the insatiable spectacle of cancel culture.

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    Biden Appointing Judges Faster Than Trump

    Biden is appointing judges faster than Trump, and most everyone else—for now @ Brookings Institute Blog.

    British Race Violence
    Severe class inequalities persist, and while it’s probably unrealistic to expect a society with which everyone can be satisfied, by European standards the British class system is still particularly pernicious. It’s not that racism has disappeared from the UK since the 1980s, but without a doubt the resistance of black and Asian communities during the decade of my birth produced very significant reforms that have changed the way my generation experiences and understands ‘race’. The gollywogs and banana skins are no longer a daily feature of black life here and neither is the Special Patrol Group, the notoriously abusive policing unit that gave almost all of the older men in my life a bloody good hiding, more than once. Though police brutality of course continues, few would deny things are far better in this respect than thirty years ago, for now at least. The physical battles fought by our parents’ generation have meant that ‘nigger hunting’ and ‘Paki bashing’ are far less common than they once were too.

    British Schizo Soul
    Britain has two competing traditions – one rooted in ideas of freedom, equality and democracy, and another that sees these words as mere rhetoric to be trotted out at will and violated whenever it serves the Machiavellian purposes of power preservation. This is how the UK can have the largest of the demonstrations against the invasion of Iraq and yet still have a government that entirely ignored its population on an issue with such globe-shifting implications.

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