“Then there was the educated Texan from Texas who looked like someone in Technicolor and felt, patriotically, that people of means – decent folk – should be given more votes than drifters, whores, criminals, degenerates, atheists and indecent folk – people without means.” – Joseph Heller
Covering: 2000 to 2015. While recent breakthroughs in the discovery of peptide antibiotics and other Peptidic Natural Products (PNPs) raise a challenge for developing new algorithms for their analyses, the computational technologies for high-throughput PNP discovery are still lacking. We discuss the computational bottlenecks in analyzing PNPs and review recent advances in genome mining, peptidogenomics, and spectral networks that are now enabling the discovery of new PNPs via mass spectrometry. We further describe the connections between these advances and the new generation of software tools for PNP dereplication, de novo sequencing, and identification.
Polyketides are a diverse class of compounds that are often created by a series of modular enzymes which condense and then modify chains of acetate or propionate units primarily through reduction, dehydration, cyclization, and aromatization reactions.
Also BioArchiv and ChemArchiv.
NIST Mass Spectrometry Data Center - in the Biomolecular Measurement Division (BMD) - develops evaluated mass spectral libraries and provides related software tools. These products are intended to assist compound identification by providing reference mass spectra for GC/MS (by electron ionization) and LC-MS/MS (by tandem mass spectrometry) as well as gas phase retention indices for GC. The Center is located on the NIST main campus in Gaithersburg, MD.
Pfizer/Moderna (i.e. NIH under US President - the patent holder) aren't sharing their vaccine recipe because they need to protect the mRNA platform, quite separately from the debate over proliferating vaccination against SARS-CoV-2 in the context of saving lives in the Coronavirus pandemic.
It's possible the big pharmaceutical corporations don't object to letting poor countries make their own vaccines. The problem is with sharing the mRNA platform itself - specifically - because it is a multipurpose technology way beyond targeting spike proteins with potential for revenue streams that dwarf the billions made from SARS-CoV-2.
The mRNA platform has myriad uses as a cancer delivery drug, which is perhaps the biggest prize in medical science - a bonanza of incalculable trillions that could roll on and on for decades. This is why the patent isn't going to be shared. It won't be shared until the technology can be shared in a way that doesn't open access beyond targeted Coronavirus usage. The vaccine corporations will doubtless be working on a nerfed version. If they find it, there will be a mainstream media fanfare of "patent sharing"; and a feeding frenzy over much unearned but irresistible political capital.
The movie Awakenings is set in a sanitarium full of patients in an awake catatonic state. In the film, a psychiatrist performs a strange experiment. He throws a tennis ball at one of the long-term catatonics and despite having been frozen for decades, since childhood, the patient catches the ball. No other movement. Still catatonic after. It's like the patient borrows the kinetic energy of the ball - overcoming the catatonic state, but only for that moment.
This is how my engagement with the world works, nowadays, with social media and infowars and "neoliberal" consumerism.
There's a headline, an article, a conversation. It has a kinetics of context and a background that might animate a fleeting interest, empathy, research - usually leading to an opinion - a conclusion, a placement within the bigger picture of society and what people do.
Then the energy is spent. No more attention to be given, no natural engagement follows. Nothing lasts. The catatonic mindset returns. Nothing changes, except perhaps an imperceptible cold petrification that began years ago, at the extremities, and has been very slowly spreading inward towards the heart.
Some guys defy odds to make a difference. Most are content being more Ballerina than reformed fat slob endurance runner David Goggins. Now and then fate gives an individual the chance to challenge their inner mettle and - very occasionally - it comes with a public stage.
Cancel culture has been perverted into a wanton spectacle of coordinated hearsay, erasing anyone it touches. There's no recourse, no appeal, no end to cancellation. The smallest offence to prurient public opinion carries as severe a punishment as the most egregious.
Someone's got to show the world how to resist; how to break the paradigm of perpetual erasure.
Someone's got to figure a way through the coruscating glare of public bloodlust, to reach those who know and support the individual.
That reconnection may have power to build new foundations, fortified against being sacrificed by the mob to feed the insatiable spectacle of cancel culture.
Biden is appointing judges faster than Trump, and most everyone else—for now @ Brookings Institute Blog.