Coronavirus Big Pharma DARPA. Vaccines Nationalism Profit.

The story of Coronavirus has been heap big fun. Informative, also, insofar as learning a lot about the way the world works – and how it’s presented, to the world, through national media, by liberal and conservative politicians, by the government and the medical communities, between different countries, etc. It’s also provided an interesting and real end-case example of how a vaccine is developed, trial’d and distributed. Most interesting of all, after doing a little research and connecting the dots, plotting the way biotech is funded, developed and utilised from the early university department papers through to ambitious use case research, to focused application answering the call for a Coronavirus vaccine once the pandemic had locked down most of the world.

Just over a year after the World Health Organisation (WHO declared Coronavirus a pandemic, vaccines are being mass-produced and distributed to populations in dozens of countries across the planet. The science has been impressive. The politics? The corporate profiteering? Quite the opposite.

“The corporate mantra is to avoid paying taxes, exploit consumers & workers at every opportunity; to squeeze the most profit from the least outlay possible. Corporate interests have pacified conservatives with money and liberals with meaningless woke jargon. Meanwhile, corporate capitalism does nothing to improve society in any form unless it profits, or costs nothing. By default this means a stratified society of winners and consumers and losers.” – @flurblewurble

“It’s going to take something more than a profit motive to give the losers a humane future but we can’t look to business to show humanity when our politicians have been corrupted. The political class must be made accountable. The ruling elites must not be allowed to enrich themselves at the cost of a fair and just society; not if we want to build a world where ‘all men are created equal’ is more than an empty tagline for a neofeudal lineage oligarchy.” – @wurbleflurble


 

mRNA vaccine
mRNA as a protective vaccine. While mRNA was originally found to be viable for in vivo gene transfer in the early 1990’s, the development of mRNA vaccines was initiated much later due to the inherent instability of mRNA compared to DNA (57). The efficacy of mRNA vaccines can be increased by several factors, such as ensuring mRNA purity, adding 5’ Kozak and cap sequences, 3’ poly-A sequences and modified nucleosides to increase mRNA stability and decrease detection by the receptors of innate immune cells, codon optimization, introduction by intramuscular, and intradermal injection to reduce RNA degradation, and by generating thermostable mRNA (57–59) (Figures 4, 5). Methods to encapsulate RNA have also been explored to increase the stability and immunogenicity of RNA vaccines, as has been used with exosome encapsulated RNA (60) and RNA-transfected dendritic cells (61, 62). When fully optimized, RNA vaccines may have an immunogenic advantage over DNA vaccines due to the presence of multiple cellular pathways that activate innate immunity in response to foreign RNA such as the toll-like receptors (TLRs) and RIG-I-like receptors (RLRs) (63, 64).
based
Twat on a brick fuckstick.

NIH (National Institutes of Health)

MODERNA

    1. NIH – Moderna – Confidential Agreements Contracts
    2. Moderna Work Against Potential Covid-19 Vaccine
    3. US govt agency BARDA awards $483 million to Moderna for Coronavirus vaccine
    4. mRNA Platform: Enabling Drug Discovery & Development

NIST (National Institute of Standards and Technology)

NIAID (National Institute of Allergy and Infectious Diseases)

EIC (European Innovation Council)

Scientists

KEI Online Coronavirus Index


CORONAVIRUS

TIMELINE OBSERVATIONS

2005

2016

2017

2018

2019

2020

COVID-19 DOCUMENTS AND ARTICLES

  1. Covid-19 Vaccine Manufacturing Capacity (April 2021)
  2. Covid-19 Vaccine Contracts (April-2020 to April 2021)
  3. Principles and guidelines for reporting on Covid-19 vaccines (22-Jan-2021)
  4. Myths and Facts about COVID-19 Vaccines (as updated 15-April-2021)
  5. Three Areas in Section 202 of the Bayh-Dole Act That Require Action to Ensure Sufficient Rights in Patents on Coronavirus Relevant Inventions
  6. Open Letter: Former Heads of State and Nobel Laureates Call on President Biden To Waive Intellectual Property Rules for COVID Vaccines
  7. May 18 Coronavirus News on CNN.com
  8. Waiving Intellectual Property Rules on COVID-19 Products
  9. Comments of James Love of Knowledge Ecology International (KEI) on the Proposal to Eliminate Unreasonable Prices as a Standalone Basis for March-in Rights (March 2021)
  10. Articles About the Role of Bill Gates in Vaccine Patent Handling (March 2020-Feb 2021)
  11. RadVac white paper – Coronavirus Vaccine Recipe (7-March-2021)
  12. BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting (24-Feb-2021)

Real life is a complicated convoluted story.